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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Triptonide, Cisplatin
Phytochemical Name Triptonide (PubChem CID: 65411 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 237
Ref_1
Pair Name Triptonide, Cisplatin
Disease Info [ICD-11: 2B72.Z] Gastric cancer Investigative
Biological Phenomena Inhibition-->Autophagy
Gene Regulation Up-regulation Expression BECN1 hsa8678
Down-regulation Expression SQSTM1 hsa8878
Up-regulation Expression MAP1LC3A hsa84557
Up-regulation Expression MAP1LC3B hsa81631
In Vitro Model MGC-803/DDP Gastric mucinous adenocarcinoma Homo sapiens (Human) CVCL_UI42
In Vivo Model A total of 32 nude mice were subcutaneously injected with AGS/DDP cells.
Result Triptonide Restore Cisplatin Sensitivity in Drug-Resistant Gastric Cancer Cells by Inhibiting Protective Autophagy
03. Reference
No. Title Href
1 Triptonide Restore Cisplatin Sensitivity in Drug-Resistant Gastric Cancer Cells by Inhibiting Protective Autophagy Click
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